垂盆草化学成分及药理作用研究进展

任凤霞,赵毅民(军事医学科学院毒物药物研究所,北京100850):垂盆草;化学成分;药理作用:R282.71:A:1004-2199(2003)01-0058-03SedumsarmentosumBunge,,,,,,[1],,,,,1[2]:(2--4-O-B-D--2-),,,,,,1.1,,,HPLC---[3]1.2[4],B-,,3B,6B--4--3,6-,3B,4A,14A,20R,24R-4,14--9(11)--3-[5]D-1998[3]D-amyrin,3-epi-D-amyrin18-B-hydroperoxy-olean-12-en-3-one[6],,,,-7-,,,,,-7-,-3,7-,,-3-,-3,7-Marion[7],,3--14-,N--2B-,[8],,,,310,,,[9][5]22.1[10],0.51.0mg/,,-6-,,ATP[11]GalNCCl4,:50mg/mlGalN510-3mol/LGPT[12]100500mg/kg,,CRBC100mg/kgPC-DTHSRBC-DTH,DTHDTH,DTH582003171ResearchandPracticeofChineseMedicinesKangH.T.[13]50150Lg/ml2448h,,G1,,[14],,ALTAST(P0.01),;ALT(P0.05),2.2[15],,T-SRBC,T,T,TWooE.R.[16]vPE16CD4+HelaHIV,,gp120-CD4100Lg/ml,80%90%[17],(211112V/V),,,,,;,T,,,,,,T,,,,MunSook-Im[18],[19],,,,,,,HBV3,,,[20]19991,2,4--1,2-,,,,,,[1],.[J].,1991,11(4):47.[2],,,.[J].,1979,(9):431.[3]HeAimin,WangMingshi,HaoHongyan,etal.Hepatoprotec-tivetriterpenesfromSedumSarmentosum[J].Phytochem-istry,1998,49(8):2607.[4],,,.[J].,1997,28(5):271.[5],,,.[J].,2001,32(4):305.[6],.[J].,1997,28(9):517.[7]MarionL.etal.CanJResearch(B),1949,27:215.[8],.[J].,2002,11(4):48.[9]HegnauerRChemotaxonoiederpflanzen(),1964,576.[10],,,.[J].,1983,3(4):237.592003171ResearchandPracticeofChineseMedicines[11],.[J].,1995,12(1):5.[12],.[J].,1995,11(5):30.[13]KangT.H.,PaeH.O.,YooJ.C.,etal.Antiproliferativeef-fectsofackaloidsfromSedumSarmentosumonmurineandhumanhepatomacelllines[J].JEthnopharmacol,2000,70(2):177.[14],,,.[J].,2001,12(10):888.[15],,,.[J].,1982,(3):145.[16]WooE.R.,YoonS.H.,KwakJ.H.,etal.Phytomedicine,1997,4(1):53.[17]..[J].2001,12(6):430.[18]MunSook-Im,RyuHong-Soo,LeeHee-Jung,etal.Han'gukYongyangsiklyongHakhoechi,1994,23(3):466.[19].[M].:,1993.338.[20],,.[J].,1999,34(1):34.(:2002-08-27)黄诺嘉,萧树雄(广东省汕头市药品检验所,广东汕头515041):拟黑多刺蚁;化学成分;药理作用:R282.74:A:1004-2199(2003)01-0060-03,26010000,2000,PolyrhachisVicinaRoger,,,,,,,,128(8),ADB1B2Bl2CE,,51.2%,,58.9%[1][2,3],,,,,1020,kg120198mg,22.1,[4][5],ISO(-51)(451),,,ISO,[6],,,[7],,,,,[8],,,DNFBDTH,602003171ResearchandPracticeofChineseMedicines