辅助生殖医学技术研究进展 刘伟信上海中医药大学

酿酒酵母基因表达的网络调控罗孟军马丹炜关萍刘少英TheyeastSaccharomycescerevisiae,whichatpresentisperhapsthebestcharacterizedmodelorganism.SpecificityandStabilityinTopologyofProteinNetworksSergeiMaslov1andKimSneppen23MAY2002VOL296SCIENCE“nullmodel”network,allproteinshaveexactlythesameconnectivityasintheoriginalone,whereasthechoiceoftheirinteractionpartnersistotallyrandom.correlationprofilesofproteininteractionandregulatorynetworksinyeastcorrelationsinconnectivitiesofneighborsItisfeasiblethatmolecularnetworksinalivingcellhaveorganizedthemselvesinaninteractionpatternthatisbothrobustandspecific.Topologically,thespecificityofdifferentfunctionalmodulescanbeenhancedbylimitinginteractionsbetweenhubsandsuppressingtheaverageconnectivityoftheirneighbors.IntegratedGenomicandProteomicAnalysesofaSystematicallyPerturbedMetabolicNetworkSCIENCEVOL2924MAY2001