药学前沿

X,(,210009),,;;;R944A1000-5048(2007)02-0097-08AdvancesonmodernpharmaceuticsZHOUJian2ping,HUOMei2rongDepartmentofPharmaceutics,ChinaPharmaceuticalUniversity,Nanjing210009,ChinaAbstractModernpharmaceuticshaveundergonearapiddevelopmentinrecentyears.Thenovelpreparationsandtechnologiesshowexpansiveforeground.Thelatestadvancesonmodernpharmaceuticshomeandabroad,includingsustained/controlled2releasedrugdeliverysystem,transdermaldrugdeliverysystem,targetingdrugdeliverysystem,smartdrugdeliverysystemandmacromoleculardrugdeliverysystem,werereviewedinthispaper.Keywordsmodernpharmaceutics;noveltechnology;novelpreparations;noveldosage2form,:,2090,,(drugdeliverysystem,DDS),1,DDS,,,,1113,,1,(),,,,(2)112()(),(),,,,(needle2freedrugdeliverysystem,NFDDS),()()(),79X2007201230XTel:025-83271272E2mail:[e-mail]euticalUniversity2007,38(2):97-104©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[1],217,,[2],[3],Poly(ethyleneglycol)2block2poly(alkylacrylate2co2methacrylicacid)[4],,156%,,,,(100m)(APCs),(),,(3)113,,,,,,ZenicaDurect2(PLGA)LHRH,2,316mg,,28d,(in2situformingdrugdeliverysystem,ISFDDS),,,ISFDDS,,,,ISFDDS43BiojectTheMedicalHousePLCActivaPowderjectHIV4,(2565)D,L2(PLA)2(PCL)PLA2PEG2PLA,60d2Ca2+,8h2pHPEG2PLGA2PEGDMSO50%,,40d89JournalofChinaPharmaceuticalUniversity38©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(transdermaldrugdeliverysystem,TDDS),(5)2.1,()12cm2,102000m(),1050m,,[5,6]:,,;,,,,DNA;2.2,,,,,,,,,[7,8][9,10],,(P0101),5(),33,()(PLAPLGA),,()()311,,,pHpH,,[11,12](proliposomes),,3(6),,,,;[13-15],,,A6/()()992:©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(lipidemulsionorfatemulsion)40,,[16-18],;,,;,,,,,,(;poloxamer188)(7),(200500nm)(100nm)(RES),RES;,,,[19];,PEG,(8),()(E1A),(),,,,,,7/,,,,,,pH()SolEmul()(),(PVP),pH8E1/,,2ADNA3132,,,,[20](9),,,PEG,,,,,,,2,,[21,22],,3(10),,,pH(pHpH)[23][24][25],[26][27]()[28],(11),(12)001JournalofChinaPharmaceuticalUniversity38©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(PLAPDLLAPLLAPLGPLGAPCL)[P(His)P(Glu)P(Asp)P(Lys)P(PBLA)]10[N,N2(DMAc)N,N2(DMF)(DMSO)],,O/W(),,,,,(),,(),(),,(DNA)11KRN25500BAK312NK2911PEO2b2P(Asp)2DOXNipponKayakuCo1,JapanSP21049CPEO2b2PPO2PEOSupratekPharma1Inc1,CanadaPAXCEEDÒPEO2b2PDLLAAngiotechGenexolÒ2PMPEO2b2PDLLASamyangCorp1,SouthKoreaNK2105PEO2b2PPBANipponKayakuCo1,Japan314[29](targetedprodrug),,(2);,PEG()22(13)1012:©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(2)()()()()()()()()PEG2,2+()2+()4,,,,,,,(pH)[30],Tanna[31]2ApH2(smartpH2sensitivemembrane2destabilisingpolymer),(),pH,,,pH,,,pH214,[32-34]14pH2AlkylacrylicacidpolymersPoly(propylacrylicacid)(PPAA)Poly(ethylacrylicacid)(PEAA)Poly(butylacrylicacid)(PBAA)Pyridyldisulfideacrylate(PDSA)Methylacrylicacid(MAA)2butylacrylate(BA)copolymers5,,,(15),[()()],,,,,15IL22IFNLHRH,(),201JournalofChinaPharmaceuticalUniversity38©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(PCL2b2PEO),[35,36],[(EGF)(FGF)RGD],,DNA,16(PLA)(PLGA)(PEI)(PLL)(ppTG1)6,,,,,[1]LingSS,MagossoE,KhanNA,etal.Enhancedoralbioavailabilityandintestinallymphatictransportofahydrophilicdrugusinglipo2somes[J].DrugDevIndPharm,2006,32(3):335-345.[2]ShenH,ZhongM.Preparationandevaluationofself2microemulsifyingdrugdeliverysystems(SMEDDS)containingatorvastatin[J].JPharmPharmacol,2006,58(9):1183-1191.[3]LuoY,ChenD,RenL,etal.Solidlipidnanoparticlesforenhancingvinpocetinesoralbioavailability[J].JControlRelease,2006,114(1):53-59.[4]SantVP,SmithD,LerouxJC.Enhancementoforalbioavailabilityofpoorlywater2solubledrugsbypoly(ethyleneglycol)2block2poly(alkylacrylate2co2methacrylicacid)self2assemblies[J].JControlRelease,2005,104(2):289-300.[5]SivamaniRK,LiepmannD,MaibachHI.Microneedlesandtrans2der2malapplications[J].ExpertOpinDrugDeliv,2007,4(1):19-25.[6]GillHS,PrausnitzMR.Coatedmicroneedlesfortransdermaldelivery[J].JControlRelease,2007,117(2):227-237.[7](LiuWA),(YeDB).[J].(ChinMedSciJ),2004,3(4):59-62.[8](SuiY),(NieZ).[J].(ChinJBasMedicTCM),2003,9(1):53-54.[9](LiuJP),(ZhuJB),(ChenSJ),.[J].(ChinAcupunc),2006,26(7):507-509.[10](ZhaoX),(LiuJP),(ZhuJB).[J].(JChinaPharmUniv),2006,37(1):28-32.[11]PonceAM,VigliantiBL,YuD,etal.Magneticresonanceimagingoftemperature2sensitiveliposomerelease:drugdosepaintingandan2titumoreffects[J].JNatlCancerInst,2007,99(1):53-63.[12]SaulJM,AnnapragadaAV,BellamkondaRV.Adual2ligandapproachforenhancingtargetingselectivityoftherapeuticnanocarriers[J].JControlRelease,2006,114(3):277-287.[13]ShahNM,ParikhJ,NamdeoA,etal.Preparation,characterizationandinvivostudiesofproliposomescontainingcyclosporineA[J].JNanosciNanotechnol,2006,6(9210):2967-2973.[14]ElhissiAM,KarnamKK,Danesh2AzariMR,etal.Formulationsgeneratedfromethanol2basedproliposomesfordeliveryviamedicalnebulizers[J].JPharmPharmacol,2006,58(7):887-894.[15]JungBH,C