8味抗艾滋病中药的性味与微量元素的相关性

3452007JOURNALOFBEIJINGUNIVERSITYOFCHEMICALTECHNOLOGYVol.34,No.5200781,211(11,100029;21,102206):8VTiMoCoCrCuFeMnNiSrZn,,,:;;;:Q631121;TQ01519:2007203213:(2002AADF3202):,1967,E2mail:[e-mail],,,[1],,,df[224][5]120,4[6]1054,4[7],,[8],,8,11,,,,,1111(HNO3)(HCl)(H2SO4),(HClO4),VTiMoCrCuMnNiSr,100g/mL;CoFeZn,1000g/mL,GBW07605(GSV24),(AVP21235G201,Aquapro),112,,,HNO3HClH2SO4HClO4,,100mLSPS8000(ICP2AES,)11ICP2AESTable1ICP2AESoperatingconditionsfordeterminationoftraceelementsintheherbs1200W0.8L/min15L/min0.6L/min0.2MPa2mL/min5s30s20s/nm309131(V),205155(Cr),228162(Co),221165(Ni),334194(Ti),324175(Cu),257161(Mn),407177(Sr),202103(Mo),213186(Zn),238120(Fe)VTiMoCoCrCuFeMnNiSrZn,GBW07605(2),GBW076052Table2AssessmentoftheaccuracyofthedigestionprocedurebycomparisonofaverageresultsobtainedwiththeGBW07605certifiedreferencematerialw/(mg/kg)V0.860.810.10Cr0.80.030.700.06Mn1240701265.6382.64Sr15.20.714.640.53Fe26415270.789.89Cu17.31.816.432.10Ti24421.682.31Zn26.32.026.820.99Ni4.60.54.520.26,n=52,4[9],[10]-minmax-=k1+r1X1-X1+r21-XX:;mixmax,3kr1r2,,3;X,(lnci),,,(lnci)8V,Ti,Mo,Co,Cr,Cu,Fe,Mn,Ni,SrZn3(4)4,X,(1),3:k=416211,r1=0111,r2=01160375,5[11],,,k4123,kr1/r25,kr11,r2/k0105;k4123,kr1/r25,kr11,r2/k0105,;k4123,kr1/r25,kr11,r2/k0105,[12214],,,,,[15],86420073Table3Concentrationofthetraceelementsindifferentherbsw/(mg/kg)VCrMoMnSrFeCuTiZnNiCo9.170.3023.891.0321.461.0922.911.526.720.149.750.570.570.0710.770.3521.452.4635.289.7043.532.3914.010.91166.8310.686.310.151.350.1316.072.2711.530.967.220.0910.690.6712.500.4319.772.6713.610.895.050.35689.685.524.540.142.910.3018.721.965.730.553.810.7814.410.3921.021.1831.885.5725.540.3316.520.60411.255.515.110.163.720.0725.810.4611.330.696.521.0314.310.5466.303.091.590.44242.6810.1649.551.68986.2717.4719.340.595.360.1110.650.223.690.2333.291.261.820.205.520.62106.222.0345.290.81787.7913.795.880.2121.140.4145.620.521.670.301.310.085.510.190.640.072.740.341.720.1440.674.121.090.302.910.2458.523.542.490.171.140.2314.040.268.520.22123.302.267.970.132.640.0712.911.07,n=54Table4ClusterstatisticsforGeraniumwilfordiiMaximw/(g/g)ci(mol/g)lncilnci+111lnci(lnci+111)X3.83887.62Sr16.520370.19-0.70.3850.0610.0652247.9Ti3.7227340.08-1.10001065.162554.938Mn25.547710.47-0.30.7770.1230.185.314295.94Mo31.887060.33-0.50.6310.10.285.462350.942V14.403290.28-0.50.5610.0890.375.53065.38Zn25.809370.39-0.40.7060.1120.485.642451.996Cr21.01620.4-0.40.7160.1130.66.092655.847Fe411.24917.360.871.9770.3130.916.262758.933Co6.5177570.11-10.1530.0240.946.342963.54Cu5.1142990.08-1.10.0150.0020.946.362858.7Ni11.322820.19-0.70.3950.0631-1.16.3151Fig.1StatisticsfitcurveofthetraceelementsdistributioninGeraniumwilfordiiMaxim,,[16],[17],k4123,kr1/r25,kr11,r2/k0105,;k4123,kr1/r25,kr11,r2/k0105,,9645:85Table5Properties,tastes,channeltropismandeffectsineightChinesemedicinalherbsandtheirclusterparameterskr1r2kr1/r2kr1r2/kk2r1/r25.4243.9430.08470.2281.460.330.065.78++++,,5.4474.0260.06460.1292.010.260.038.08+++-,,5.3783.7810.29360.3902.851.110.1010.76++-+;,,,5.954.620.110.163.170.510.0314.65-++-,,,,()5.564.630.200.204.580.930.0421.18-++-,,,[18219],[20],[6],k4123,kr1/r25,kr11,r2/k0105,,,[21222]8,,,,,[23]38,,VTiMoCoCrCuFeMnNiSrZn,,,,,,;;r1r2,,,r1r2,,,:[1]WANGMei,LAMERSRJ,KORTHOUTHA,etal.Metabolomicsinthecontextofsystemsbiology:BridgingtraditionalChinesemedicineandmolecularpharmacology[J].PhytotherapyResearch,2005,19:173-182.[2]TAPIEROH,TEWKD.Traceelementsinhumanphysiologyandpathology:Zincandmetallothioneins[J].Biomedicine&Pharmacotherapy,2003,57:399-411.[3]TAPIEROH,TOWNSENDDM,TEWKD.Traceel2ementsinhumanphysiologyandpathology.Copper[J].Biomedicine&Pharmacotherapy,2003,57:386-398.[4]CESARGF.Relevance,essentialityandtoxicityoftraceelementsinhumanhealth[J].MolecularAspectsofMedicine,2005,26:235-244.[5],,,.[J].,2003,20(4):449-452.[6],,,.4[J].,1990,5(5):40-43.[7],,.[J].,1998,26(11):1309-1314.[8],.4(IV)[J].0742007,2003,30(5):52-54.[9].4JRG[M].:,1999.[10],.4()[J].,2002,29(6):44-49.[11],,.()()(II)[J].,2003,5(4):11-15.[12],,,.[J].2,2003,24(10):1108-1111.[13],,,.[J].,2006,4(1):73-76.[14]WANGHuamin,ACTORJK,INDRIGOJ,etal.AsianandSiberianginsengasapotentialmodulatorofim2munefunction:Aninvitrocytokinestudyusingmousemacrophages[J].ClinicaChimicaActa,2003,327:123-128.[15],.(VI)[J].,2004,6(2):15-19.[16],,,.[J].:,2006,25(1):35-38.[17],,.[J].,2005,33(4):66-69.[18],,.[J].,2006,31(7):538-541.[19],.[J].,1995,5(2):78-82.[20],,.[J].,2005,16(9):840-841.[21],,.[J].,2002,23(8):748-749.[22],,,.[J].,2004,26(1):59-65.[23],,.[J].,2005,20(5):5-7.Acorrelationbetweentheanti2HIVpropertiesofChinesemedicinalherbsandtheirtraceelementcontentZHAOJun1,2JINRiGuang1LUOLu1(11CollegeofMaterialsScienceandEngineering,BeijingUniversityofChemicalTechnology,Beijing100029;21NationalInstituteofPharmaceuticalResearch&DevelopmentCoLtd,Beijing102206,China)Abstract:TheabundancesofV,Ti,Mo,Co,Cr,Cu,Fe,Mn,Ni,SrandZnineightmedicinalherbsweredeterminedbyinductivelycoupledplasmaatomicemissionspectrometry(ICP).Thedistributionoftraceelementconcentrationsintheeightmedicina