复方中药侯氏黑散发挥维持神经血管单元内环境稳定的作用途径

SICENCE新闻发布作者：王海征稿号：N201306029复方中药侯氏黑散发挥维持神经血管单元内环境稳定的作用途径脑缺血不仅损伤神经元，而且会累及对神经元起支持作用的胶质细胞及为神经组织供能的微血管。因此，要使神经功能恢复，不能仅局限于单一神经元保护，而应着眼于对整个“神经血管单元”功能的维护。中药复方侯氏黑散是治疗脑卒中的有效复方中药之一，全方由风药（菊花、防风、细辛、桂枝、川芎、桔梗）和补虚药（人参、当归、白术、茯苓、干姜）组成。首都医科大学中医药学院王海征所在课题组进行的一项研究显示，侯氏黑散方中的“风药”、“补虚药”相辅相成，可通过下调β淀粉样蛋白的表达，抑制淀粉样前体蛋白异常积聚，减少淀粉样物质沉积，维持神经血管单元内环境的稳定，从而保护神经血管单元。文章发表在《中国神经再生研究（英文版）》杂志2014年4月第7期。苏木精伊红染色显示，侯氏黑散灌胃脑缺血大鼠模型，脑缺血半暗带区神经细胞数量明显增多，有少量炎细胞浸润Article:Houshiheisancompoundprescriptionprotectsneurovascularunitsaftercerebralischemia,byHaizhengWang,LeiWang,NanZhang,QiZhang,HuiZhao,QiuxiaZhang(SchoolofTraditionalChineseMedicine,CapitalMedicalUniversity,Beijing,China)WangHZ,WangL,ZhangN,ZhangQ,ZhaoH,ZhangQX.Houshiheisancompoundprescriptionprotectsneurovascularunitsaftercerebralischemia.NeuralRegenRes.2014;9(7):741-748.欲获更多资讯：NeuralRegenResSICENCE新闻发布作者：王海征稿号：N201306029HoushiheisanmaintainsstabilizationoftheinternalenvironmentofneurovascularunitsCerebralischemianotonlyinjuriesneurons,butalsoinvolvestheglialcellsthatprovideasupportivescaffoldtowhichtheneuronsareattachedandthemicrovesselsthatprovideenergyfornervoustissue.Therefore,protectionofasingleneuronisnotsufficienttorecovernervousfunction,andmoreattentionshouldbepaidtomaintenanceofthefunctionofentireneurovascularunits.HoushiheisancompoundisoneofeffectivetraditionalChinesecompoundprescriptionsforstroke.Theprescriptioniscomposedofwind-dispelling(chrysanthemunflower,divaricatesaposhnikoviaroot,Manchurianwildginger,cassiatwig,Szechwanlovagerhizome,andplatycodonroot)anddeficiency-nourishing(ginseng,Chineseangelica,large-headatractylodesrhizome,Indianbread,andzingiber)drugs.HaizhengWangandhisteam,SchoolofTraditionalChineseMedicine,CapitalMedicalUniversityinChina,performedastudyonHoushiheisanandfoundthatthewind-dispellinganddeficiency-nourishingdrugsinthecompoundprescriptionHoushiheisanarecomplementarytoeachother,effectivelysuppressabnormalamyloidprecursorproteinaccumulation,reduceamyloidsubstancedeposition,maintainstabilizationoftheinternalenvironmentofneurovascularunits,andminimizeinjurytoneurovascularunitsintheischemicpenumbrabydownregulatingtheamyloid-βexpression.TheirfindingswerepublishedinNeuralRegenerationResearch(Vol.9,No.7,2014).Hematoxylin-eosinstainingrevealedthatafterintragastricadministrationofHoushiheisan,thenumberofnervecellswasvisiblyincreasedandtherewasinfiltrationofasmallnumberofinflammatorycellsintheischemicpenumbraofratswithcerebralischemia.Article:Houshiheisancompoundprescriptionprotectsneurovascularunitsaftercerebralischemia,byHaizhengWang,LeiWang,NanZhang,QiZhang,HuiZhao,QiuxiaZhang(SchoolofTraditionalChineseMedicine,CapitalMedicalUniversity,Beijing,China)WangHZ,WangL,ZhangN,ZhangQ,ZhaoH,ZhangQX.Houshiheisancompoundprescriptionprotectsneurovascularunitsaftercerebralischemia.NeuralRegenRes.2014;9(7):741-748.