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5.J.2005199592-594.6.J.200319755-56.7.J.2002153136-138.8.J.201016162-63.9.J.2008817-9.10.J.2006411264.11.J.2012126441-442.12.J.2009910144-145.2014-01-02··511400【】【】R591.1【】A【】1674-3296201403B-0176-03135~145mmol/L<135mmol/L、、。、、、、、、SIADH。OtsukaPharmV22009519FDA、SIADHV2。。3~4mmol/L。。。AVP。。11.1EVERESTEVEREST1、2、、22003107-200623、35941339.9。、。、、2、。、。1、17。。Blair3EVEREST12516885641619。1.2UdelsonUdelsonLVEDV1LV。4。Udelson5、48181LVEF23%NYHAⅢPCWP18mmHg1mmHg=0.133kPa15、30、60mg3PCWP、3h·671·2014373ChinJofClinicalRationalDrugUseMarch2014Vol.7No.3B。1.3Ferrer。5000、、6。1.4GheorghiadeGheorghiade7、、3411≥181159330、6090mg9∶00AMJVD、。1、10749~51。60d。24h60d、。31P0.02<0.001<0.001、、。Gheorghiade7ACTIV-CHF31930~90mg/d24hP<0.00168。25430~60mg125P<0.00170180%40%P<0.058。>135mmol/L≥10%10~60mg/d27d9。1.5PangPang10。22.11138++7d。1122~3d。2.21215、30、60120mg48h、、24hP>0.05。15、30、60120mg24h。6~12h5.1~7.3mmol/L。320124MHRA、、、。4<800ml13、、1~5h≤6mmol/L6~12h≤8mmol/L14。2012430FDA。1400ADPKD、3、。90mg30mg60mg3。FDA、、、。、。。。1GheorghiadeMKonstamMABurnettJCJretal.Short-termclinical·771·2014373ChinJofClinicalRationalDrugUseMarch2014Vol.7No.3Beffectsoftolvaptananoralvasopressinantagonistinpatientshospital-izedforheartfailureTheEVERESTClinicalStatusTrialsJ.JAMA2007297121332-1343.2GheorghiadeMKonstamMABurnettJCJretal.Effectsoforaltolvap-taninpatientshospitalizedforworseningheartfailureTheEVERESTOutcomeTrialJ.JAMA2007297121319-1331.3BlairJZannadFKonstamMetal.ContinentaldifferencesinclinicalcharacteristicsmanagementandoutcomesinpatientshospitalizedwithworseningheartfailureJ.JAmCollCardio200852201640-1648.4UdelsonJEMcGrewF.Aetal.MulticenterRandomizedDouble-BlindPlacebo-ControlledStudyontheEffectofOralTolvaptanonLeftVentricularDilationandFunctioninPatientsWithHeartFailureandSystolicDysfunctionJ.JAmCollCardiol200749222151-2159.5UdelsonJ.EOrlandiCOuyangJetal.Acutehemodynamiceffectsoftolvaptanavasop-ressinV2receptorblockerinpatientswithsymptomat-icheartfailureandsystolicdysfunctionJ.JAmCollCardiol200852191540-1545.6FerrerE.TolvaptanforthetreatmentofhyponatremiaandcongestiveheartfailureJ.DrugsTodayBaric20104631632-1671.7GheorghiadeMGattisWAO'ConnorCMetal.Effectsoftolvaptanavasopressinanagonistinpatientshospitalizedwithworseningheartfail-ureJ.JAMA2004291161963-1971.8GheorghiadeNiaziIOuyangJetal.VasopressinV2-receptorblockadewithtolvaptaninpatientswithchronicheartfailureresultsfromadoub-le-blindrandomizedtrialJ.Circulation2003107212690-2696.9GheorghiadeMCottlibeSSUdelsonJEetal.VasopressinV2-receptorblockadewithtolvaptanversusfluidrestrictioninthetreatmentofhy-ponatremiaJ.AmJCardiol20069771064-1067.10PangPKonstamMKrasaHetal.Effectsoftolvaptamondyspnoeare-lieffumtheEVERESTtrialsJ.JAmCollCardiol200852201640-1648.11.J.2011285387-389.12.J.2008172160-164.13.J.201093271-272.14MHRA.DrugSafetyUpdate.Tolvaptanover-rapidincreaseinserumso-diumandriskofseriousneurologicaleventsEB/OL.2012-4-19.2014-01-18··421001【】【】R543.5【】A【】1674-3296201403B-0178-03VSMC1~3。VSMC。VSMC、VSMC、VSMC2。VSMCVSMC4。VSMC。、。。2354'--2-O-β-DTSG、、、、5~9。TSG。12354.--2-O-β-DTSG101406.39。TSG80℃。、、、。12·871·2014373ChinJofClinicalRationalDrugUseMarch2014Vol.7No.3B
本文标题:托伐普坦的国内外临床研究进展-江冬青
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